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Synthesis of Tomoxetine (R isomer)
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(1): Summary
This drug can be synthesized by various approaches. Those different approaches have been reported in the following patents,
US 4018895, EP 0052492, EP 0193405, WO 0058262, WO 0061540, WO02057475
and research papers:
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Tetrahedron Letters, 35(9), 1339-1342, 1994 |
| Journal of Organic Chemistry, 1985, 50, 5446-5448 |
| Tetrahedron Letters, 30(39), 5207-5210, 1989 |
| J.Amer.Chem.Soc.109, 5551, 1987 |
| J.Amer.Chem.Soc.109, 7925, 1987 |
| J. Org. Chem., 53, 2861, 1988 |
| J. Org. Chem., 1988, 53, 4081-4084 |
| J.Amer.Chem.Soc.109, 5765-5780, 1987 |
| Bioorganic & Medicinal Chemistry, 4(6), 877-880, 1996 |
| Tetrahedron: Asymmetry, 3(4), 525-528, 1992 |
| Tetrahedron Letters, 43, 5435-5436, 2002 |
| Tetrahedron, 53(20), 6739-6746, 1997 |
| Tetrahedron, 45, 5767, 1989 |
| Tetrahedron Letters, 37, 2683, 1996 |
| Tetrahedron Letters, 32(16), 1901-1904, 1991 |
| J.Chem. Soc, Perkin Trans., 1, 1767-1769, 2000 |
| Adv. Synth.Catal. 345, 261-274, 2003; |
| J.Amer.Chem.Soc. 109, 5856, 1987 |
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| (2): Retro-synthetic routes analysis
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